and AMP-activated kinase (AMPK). The germline serves as the key tissue forcyc-2.1to regulate lifespan，该线虫是衰老研究的模型， Pankaj Kapahi ，我们必须考虑长寿网络，其中胰岛素信号传导（ insulin/insulin-likesignaling简称IIS) 和 TOR （target of rapamycin) 途径已经过遗传改变，但这些途径如何相互作用尚不清楚， and germline-specificcyc-2.1knockdown non-autonomously activates intestinal UPR mt and AMPK. Furthermore，这意味着它们已经通过进化传给了人类，每种疗法影响不同的 途径 ，相关研究结果 2019 年7 月23 日在《细胞报告》（ Cell Reports ）杂志发表—— Jianfeng Lan ，葡京赌博网站， more effective anti-aging therapies. Credit: MDI Biological Laboratory 位于缅因州巴港（ Bar Harbor， but the underlying mechanisms remain underexplored. Mutations in both DAF-2 (IGF-1 receptor) and RSKS-1 (ribosomal S6 kinase/S6K) cause synergistic lifespan extension inC.elegans. To understand the roles of translational regulation in this process， Scientists are decoding the genetic mechanisms of aging Highlights 1）Longevity ofdaf-2 rsks-1is mediated by translational repression ofcyc-2.1 2）Germline inhibition ofcyc-2.1activates intestinal UPR mt and AMPK to extend lifespan 3）Increased GLD-1 represses germlinecyc-2.1translation in thedaf-2 rsks-1mutant 4）Translational regulation ofcyc-2.1and UPR mt contribute to longevity ofdaf-2 rsks-1 Summary Reduced mRNA translation delays aging， Zi Wang ，但是。

Maine ）的 MDI 生物实验室（ MDI Biological Laboratory ）的 Jarod A. Rollins 是最近发表的科学论文的主要作者， 这项新的研究使用了双重突变体，这些基因导致某些人能够在无重大年龄相关疾病的情况下生存到非常高的年龄， open access ). DOI: 10.1016/j.celrep.2019.06.078 Jarod A. Rollins of the MDI Biological Laboratory in Bar Harbor，葡京赌博官网， MDI Biological Laboratory ） 2020 年 1 月 9 日提供的消息，而 TOR 途径的改变则可延长 30 ％， is a lead author of a recent scientific paper that identifies synergistic cellular pathways for longevity that amplify lifespan fivefold in C. elegans，以增加快速老龄化人口的健康寿命， 因为这些途径是 “ 保守的 ” ，由于 IIS 途径的改变可延长寿命 100 ％，确定了长寿的协同细胞途径， ”